The author review almost inflationary and vague use of the concept human dignity.It is more regulatory principle, than general notion with standardized meaning.Its philosophical, theological, legal and bioethical dimensions are emphasized.The principle of human dignity is constitutive not only for the moral but also for modern society, the foundati
AbstractLampetra zanandreai (Vladykov, 1955) is a non-parasitic, freshwater lamprey endemic to the ancient Po basin.A few, mostly very dated studies have investigated some aspect of the biology of this lamprey, but surprisingly, despite it being considered a threatened species, information on its ecology is practically absent.Specifically, informat
Abstract Epithelial ovarian cancer is the most lethal gynecological malignancy, owing notably to its high rate of therapy-resistant recurrence in spite of good initial response to chemotherapy.Although poly(ADP-ribose) polymerase inhibitors Frosted Lantern (PARPi) have shown promise for ovarian cancer treatment, extended therapy usually leads to ac
Despite the various roles of type I interferon (type I IFN) responses during bacterial infection, its specific effects in vivo have been poorly characterized in scrub typhus caused by Orientia tsutsugamushi infection.Here, we show that type I IFNs are primarily induced via intracellular nucleic acids sensors, including RIG-I/MAVS and cGAS/STING pat